NeuroChemistry

NeuroChemistry

NeuroChemistry

and NeuroDevelopment - Neuro Chemistry
NeuroChemistry
Neuro Chemistry or NeuroChemistry
Studies metabolic and biochemical agents in the brain. Nucleic acids - DNA, RNA.
Brain content high during early phases of development, then gradually decreases.
DNA content is a reliable predictor of cell number.
Two periods of cell proliferation detected by measuring DNA: 15-20 wks gestation is neuroblast proliferation; 25 wks gestation to 2 yrs age glial cell multiplication
Lesch-Nyhan syndrome - mutation of gene affects enzyme involved in making of nucleotide bases of nucleic acids
Amino acids :
Absorption of amino acids from blood and rates of protein synthesis higher for newborns than adults
Inborn errors of amino acid metabolism - PKU
Lipid :
In fetal brain, little difference found between lipids in gray and white matter
Adult pattern attained during myelination, which increase in three major lipids (cholesterol, cerebrosides, sphingomyelin)
Disorders of lipid metabolism - Tay-Sachs, Niemann-Pick
Neurotransmitters :
dopamine, acetylcholine, epinephrine, norepinephrine, glutamate
increase in levels serve as developmental signals for neural tube formation, germinal cell proliferation, and neuronal and glial differentiation
Neurodevelopment Chemistry 2025
New Biomarkers: Advancing Our Knowledge of Children’s Neurodevelopment and Chemical Exposures U.S. Environmental Protection Agency (.gov)
Using machine learning to investigate the influence of the prenatal chemical exposome on neurodevelopment of young children ScienceDirect
Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption ACS Publications
Research reveals unexpected roles of TEAD proteins in neurodevelopment EurekAlert!