NeuroChemistry |
NeuroChemistryand NeuroDevelopment - Neuro Chemistry |
| NeuroChemistry |
| Neuro Chemistry or NeuroChemistry |
| Studies metabolic and biochemical agents in the brain. Nucleic acids - DNA, RNA. |
| Brain content high during early phases of development, then gradually decreases.
DNA content is a reliable predictor of cell number. Two periods of cell proliferation detected by measuring DNA: 15-20 wks gestation is neuroblast proliferation; 25 wks gestation to 2 yrs age glial cell multiplication Lesch-Nyhan syndrome - mutation of gene affects enzyme involved in making of nucleotide bases of nucleic acids |
| Amino acids :
Absorption of amino acids from blood and rates of protein synthesis higher for newborns than adults Inborn errors of amino acid metabolism - PKU |
| Lipid :
In fetal brain, little difference found between lipids in gray and white matter Adult pattern attained during myelination, which increase in three major lipids (cholesterol, cerebrosides, sphingomyelin) Disorders of lipid metabolism - Tay-Sachs, Niemann-Pick |
| Neurotransmitters :
dopamine, acetylcholine, epinephrine, norepinephrine, glutamate increase in levels serve as developmental signals for neural tube formation, germinal cell proliferation, and neuronal and glial differentiation |