Ehp Niehs Nih Members 2005 8030

Ehp Niehs Nih Members 2005 8030

Neuro Development
has unveiled a new cause for concern: In the January 2006issue of EHP, child psychiatry professor Gail Wassermanand colleagues from Columbia University reported that Bangladeshichildren who drank well water with high concentrationsof naturally occurring manganese had diminished intellectualfunction. the researchers noted that the bioavailabilityof manganese in water is higher than that of manganesein food. They also pointed out that about 6% of U.S. wellshave a high enough manganese content to potentially putsome children at risk for diminished intellectual function.the cellular and molecular mechanisms of manganese neurotoxicityare not well understood. the dopaminergic system in thebasal ganglia, which is affected in Parkinson disease,may be involved, but this hypothesis is controversial.Toma Guilarte, a professor of molecular neurotoxicologyat the Johns Hopkins Bloomberg School of Public Health,described research on these systems in nonhuman primatesat the XXII International Neurotoxicology Conference. Accordingto Guilarte, unpublished positron-emission tomography studiesof the basal ganglia show that manganese does appearto have an effect on dopaminergic neurons. Guilartefound that the more manganese the animals received, theless dopamine was released through the actions of amphetamine(which is used to induce the release of the neurotransmitter). Thisdoes not mean that manganese causes Parkinson’s disease,merely that it has an effect on those neurons, hesays. This is the first report of an in vivo effect

Ehp Niehs Nih Members 2005 8030

Web Site
Ehp Niehs Nih Members 2005 8030 8030 - Toxins - Find in Neurodevelopment and Health
Ehp Niehs Nih Members 2005 8030 8030 - Toxins in Neurodevelopment and Health

Ehp Niehs Nih Members 2005 8030 Neurodevelopment
Ehp Niehs Nih Members 2005 8030 2018