|Ehp Niehs Nih Members 2005 7691|
Ehp Niehs Nih Members 2005 7691
A study reported in the September 2005 issue of EHP foundthat there were significant effects on a child’s IQ even when blood lead concentrations were below 10 ug/dL.Upon the July 2005 release of the Third National Report on Human Exposure to Environmental Chemicals bythe CDC, Jim Pirkle, deputy director for science at the CDC’s Environmental Health Laboratory, stated, Thereis no safe blood [lead] level in children.Several groups have also found evidence that lead exposuremay shape a child’s social behavior. An Environmental Research reportsa strong correlation, dating back to 1900, between violentcrime and the use of lead- Based paint and leaded gasoline.the research complements studies found that bone leadlevels in young males were correlated with aggression andcriminality. Lead is significantly associated witha risk for delinquency. (Needleman research in the November-December 2002Neurotoxicology and Teratology)Another new area of research links early lead exposureto changes in the aging brain. Nasser Zawia, an associateprofessor of pharmacology and toxicology at the Universityof Rhode Island, Kingston, and his colleagues found increasedexpression of amyloid precursor protein (APP) and its product, ?-amyloid(which is a hallmark of Alzheimer disease), in aging ratsthat were exposed to lead shortly after birth. In contrast,old rats that were exposed to lead did not show an increasedexpression of APP and ?-amyloid.the work, published in the 26 January 2005 issue of TheJournal of Neuroscience, suggests that early exposureto lead can reprogram gene expression andregulation later in life. According to Zawia, preliminaryresearch also shows that monkeys exposed to leadas infants exhibit similar molecular changes as well asexaggerated Alzheimer’s pathology.
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Ehp Niehs Nih Members 2005 7691 7691 - Toxins - Find in Neurodevelopment and Health
|Ehp Niehs Nih Members 2005 7691 7691 - Toxins in Neurodevelopment and Health|
|Ehp Niehs Nih Members 2005 7691 Neurodevelopment|